Title	Drive From St. Louis to Indianapolis
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Description	Looking to go from St. Louis to Indianapolis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
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Drive From St. Louis to Indianapolis

Are you looking to take a road trip? A rental car from your local neighborhood Enterprise location might be the best option for your travel! Enterprise offers quick, convenient travel options so you can get on the road faster. With so many styles and options available, you’re sure to find the perfect rental car for your travels.

Drive time: approx. 3.75 hours (Driving Directions)

Distance: approx. 250 miles

Benefits of Renting a Car

Reduce wear-and-tear and/or mileage on your own vehicle
Choose from a variety of rental cars – like compacts, minivans or luxury SUVs – to fit your group’s needs
Select a style with extra cargo space – perfect for camping gear, hiking equipment or that last-minute RSVP
Enjoy add-ons such as car seats, GPS/navigational systems, ski racks and more

Popular Road Trip Cars

Take your pick from one of these classic road trip car options.

SUVs

Our SUVs offer flexibility with seating capacity, power, and luggage room. Find the ideal SUV for your next weekend family trip or exploring the countryside.

Rent an SUV

Trucks

Looking to haul large items for DIY projects or going on a weekend retreat? A pickup truck has space, power and durability ideal for your project or trip.

Rent a Truck

Vans

Need extra room for people, luggage, or cargo or both? Our minivans and passenger vans can seat up to 7 and 15 people and are great for family vacations or large groups.

Rent a Van